Role of Stem Cell Therapy in Diabetic Cardiomyopathy in Rats: Histological and Immunohistochemical study

Background: Diabetes mellitus is one of the main causes death due to complications that involve many organs such as heart, kidney, retina and others. Mesenchymal stem cell (MSC) has been demonstrated be effective in treatment diabetes. Aim work: To evaluate effect cells diabetic cardiomyopathy clarifying their role oxidative stress inflammation. Material methods: 30 adult male albino rats were equally divided into 3 groups: control group (group I): received 1ml saline by intra-peritoneal (IP) injection. Streptozotocin-treated II): Streptozotocin (STZ) (60mg/kg BW, I.P.) for induction diabetes then sacrificed after 4 weeks. Steptozotocin+ Stem cell-treated III): STZ they left weeks injected once intravenously with 1 million units MSC The heart sections examined Histologically H&E Masson’s Trichrome Stain Immunohistochemically endothelial Nitric Oxide Synthase (eNOS). A morphometric study statistical analysis performed. Results: DM caused inflammation, degeneration, fibrosis decreased eNOS Immunoexpression cardiac muscle fibers. administration MSCs improved pathological changes increased heart. Conclusion: proved have therapeutic treating